EffePharm’s New Toxicological Studies Confirm NMN Safety: Interpretation of Findings & Summary of Recent 5-Year NMN Clinical Trials

Time: 2024-08

EffePharm has recently released the results of toxicological tests on NMN (Nicotinamide Mononucleotide, a form of Vitamin B3), confirming its safety. NMN is crucial for human cells, as it is naturally produced in the body and is also found in many foods. It acts as a key building block for NAD+ (a coenzyme essential for combating aging and various diseases).

Nicotinamide adenine dinucleotide (NAD+) is an essential molecule involved in many cellular processes. However, NAD+ levels decline with age, which is linked to age-related diseases. Our cells primarily produce NAD+ from its precursor, NMN.

This innovative study, the first of its kind, investigated the genetic toxicity of NMN using an in vivo mammalian bone marrow model. The results were encouraging, showing that even at high doses of 2,000 mg/kg body weight, oral NMN did not exhibit any signs of genetic toxicity, supporting its strong safety profile. Recent human trials have found that higher NAD+ levels can lead to various health benefits, such as improved cognitive and sensory functions, better insulin sensitivity in muscles, and increased activity in skeletal muscles.

Read the full article here:

https://doi.org/10.1016/j.crtox.2024.100171

 

Additionally, We have collected the NMN clinical studies in the last 5 years, you can access them online:

In 2020

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthyJapanese men

In 2021

  1. The impacts of short-term NMN supplementation on serum metabolism, fecal microbiota, and telomere length in pre-aging phase

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

  1. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study
  2. 2022 Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men
  3. Effect of 12-week intake of nicotinamide mononucleotide on sleep quality, fatigue, and physical performance in older Japanese adults: a randomized, double-blind placebo-controlled study
  4. A multicentre, randomised, double blind, parallel design, placebo controlled study to evaluate the efficacy and safety of uthever (NMN supplement), an orally administered supplementation in middle aged and older adults
  5. Safety evaluation of beta-nicotinamide mononucleotide oral administration in healthy adult men and women
  6. Clinical evaluation of changes in biomarkers by oral intake of NMN
  7. Oral administration of nicotinamide mononucleotide is safe and efficiently increases blood nicotinamide adenine dinucleotide levels in healthy subjects

MIB-626, an oral formulation of a microcrystalline unique polymorph of β-nicotinamide mononucleotide, increases circulating nicotinamide adenine dinucleotide and its metabolome in middle-aged and older adults

  1. The efficacy and safety of β‑nicotinamide mononucleotide (NMN) supplementation in healthy middle‑aged adults: a randomized, multicenter, double‑blind, placebo‑controlled, parallel‑group, dose‑dependent clinical trial
  2. Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals

Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study

In 2023

  1. Nicotinamide adenine dinucleotide metabolism and arterial stifness after long‑term nicotinamide mononucleotide supplementation: a randomized, double‑blind, placebo‑controlled trial
  2. Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study
  3. Nicotinamide mononucleotide (NMN) intake increases plasma NMN and insulin levels in healthy subjects
  4. Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

In 2024

  1. Ingestion of β‑nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improvedsleep quality in older adults in a double‑blind randomized, placebo‑controlled study
  2. Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men