Obesity is associated with adipose tissue dysfunction and multi-organ insulin resistance. Administrating NMN improved multi-organ insulin sensitivity, increased adiponectin production, and decreased free fatty acids production. Feeding mice with drinking water containing NMN inhibited age-induced weight gain. NAD+ and NAMPT levels decrease in multiple organs during aging, and NMN improves glucose intolerance and lipid profiles in age-induced Type 2 Diabetes mice. NMN is a potential nutriceutical intervention against diet- and age-induced Type 2 Diabetes.